Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics. MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment.
*Sold in collaboration with Biofordrug srl
KEYWORDS: MC70 hydrochloride | supplier | P-gp inhibitor | MC-70 | MC 70 | CAS [2108830-71-1] | [1031367-64-2] | PGP | ABC transporter | ABCB1 | MDR1 | BCRP | Caco-2 | breast cancer | Non Selective | P-glycoprotein | Inhibitor | Proteins