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Axon 2574
CAS [1073154-85-4]
MF C20H21F3N8O3SMW 510.49
Orally available second-generation inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (PYK2) with an acceptable safety profile in clinical trials (IC50 values 0.6 nM for each kinase, and >100-fold greater selectivity for FAK and PYK2 than for other, non-target kinases). Structurally closely related to PF 431396 (Axon 2107).
KEYWORDS: Defactinib | supplier | FAK/PYK2 inhibitor | VS 6063 | PF 04554878 | PF04554878 | VS6063 | PF4554878 | CAS [1073154-85-4] | [1073160-26-5] | Phosphorylation | FAK | PYK2 | Inhibitor | focal adhesion kinase | proline-rich tyrosine kinase-2 | solid | tumor | malignancies | prostate cancer
N-methyl-4-(4-((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide
[1073154-85-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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