OTX 015

Based on 345 reference(s) in Google Scholar 10 10 345

Axon 2530

CAS [202590-98-5]

MF C25H22ClN5O2S
MW 491.99

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO and ethanol

OTX 015

Description

Potent inhibitor of BRD2, BRD3, and BRD4 (Ki values ranging from 3.2 to 24.7 nM, considering BDs 1 and 2), with clear anti-proliferative activity on a large number of diffuse large B-cell lymphoma (DLBCL) cell lines. OTX 015 inhibits the growth of hematologic malignances through directly regulating MYC expression and activity.

M. Boi et al. The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.Clin Cancer Res. 2015 Apr 1;21(7):1628-38.

J. Lu et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63.

X. Ran et al. Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem. 2015 Jun 25;58(12):4927-39.

Potent inhibitor of BRD2, BRD3, and BRD4 with clear anti-proliferative activity

Chemical name

(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide

Parent CAS No.

[202590-98-5]

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Size	Unit Price	Stock
5 mg	€110.00	In Stock
25 mg	€370.00	In Stock

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OTX 015

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