GSK046
- iBET-BD2
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C23H27FN2O4
- MW: 414.47
Description
GSK046 is a domain-selective and orally active inhibitor of BET with immunomodulatory activity, targeting specifically BDII (Bromodomain II) with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
More Information
| Parent CAS No. | 2474876-09-8 |
|---|---|
| Chemical Name | 4-Acetamido-3-fluoro-N-((1r,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(O[C@H](C2C=CC=CC=2)C)C(NC(=O)C)=C(F)C=C(C(N[C@@H]2CC[C@@H](O)CC2)=O)C=1 |&1:2,21,24,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18?,19?/m0/s1 |
| InChiKey | FRBRZGLUFOZRGD-YCMKEVRSSA-N |
| CID | 146018690 |
| Short Description | BET inhibitor |
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