BMS-986158
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C30H33N5O2
- MW: 495.62
Description
BMS-986158 is an orally bioavailable, potent and domain-selective BET protein inhibitor, binding to the acetyl-lysine binding site of BET bromodomain of BRD4 (Bromodomain-containing 4) with an IC50 < 5nM (FRET). Display excellent pharmacokinetic properties and efficacy in vitro and in vivo antitumor activity.
More Information
| Parent CAS No. | 1800340-40-2 |
|---|---|
| Chemical Name | (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1([C@@H](N2C3C=C(C(O)(C)C)C=CC=3C3N=CC(C4N(C)N=NC=4C)=CC2=3)C2CCOCC2)C=CC=CC=1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1 |
| InChiKey | KGERZPVQIRYWRK-GDLZYMKVSA-N |
| CID | 118196485 |
| Short Description | BET bromodomain (BRD4) inhibitor |
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