Bulk Inquiry
(+)-JQ1 carboxylic acid
- Optical Purity: Optically pure
- Soluble 0.1N NaOH(aq), DMSO and EtOH
- MF: C19H17ClN4O2S
- MW: 400.88
Description
(+)-JQ1 carboxylic acid is a derivative of (+)-JQ1 (Axon 1989), which is a potent and selective BET bromodomain inhibitor. (+)-JQ1 carboxylic acid can be used as a precursor to synthesize PROTACs, which target BET bromodomains.
More Information
| Parent CAS No. | 202592-23-2 |
|---|---|
| Chemical Name | (S,Z)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid |
| SMILES | [C@@H]1(CC(O)=O)N=C(C2C=CC(Cl)=CC=2)C2C(C)=C(C)SC=2N2C(C)=NN=C12 |&1:0,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1 |
| InChiKey | LJOSBOOJFIRCSO-AWEZNQCLSA-N |
| CID | 66828107 |
| Short Description | (+)-JQ1 derivative |
References
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