BRPFs (bromodomain and PHD finger-containing proteins) are multidomain proteins of the Trithorax group (TrxG): regulatory proteins composed of diverse, evolutionary conserved units that form chromatin-associated complexes accounting for epigenetic transcriptional memory. Three BRPFs are known to date, sharing >65% homology in their ~100 amino acid counting sequences, all sharing an acetylated lysine (KAc) recognition site that closely resembles other bromodomains, including those of the BETs. BRPF1 (also known as Br140 and Peregrin) is a component of complexes containing the MOZ/MORF transcriptional coactivators, that links the catalytic HATs to the other subunits ING5 and hEAF6. Furthermore, BRPF1 contains PHD fingers, a bromodomain and a PWWP domain. It has been shown that BRPF1 has a central role during development, since mutations have shown to display anterior transformations of pharyngeal arches due to progressive loss of anterior Hox gene expression. What’s more, translocations of MOZ are associated with aggressive subtypes of leukemia, and make BRPF1 an interesting target in oncology related research.