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ANA 12
Axon 2468
CAS:
219766-25-3
Purity:
100%
- Soluble in DMSO
- MF: C22H21N3O3S
- MW: 407.49
Description
Selective TrkB antagonist (IC50 value 45.6 ± 8.4 nM for the high-affinity TetOn-rhTrkB) with anxiolytic and antidepressant activity in mice that inhibits processes downstream of TrkB without altering TrkA and TrkC functions. A valuable tool for studying BDNF/TrkB signaling. ANA-12 is also capable of reversing the diminished self-administration of cocaine in male CocSired rats by means of enhanced BDNF expression.
More Information
| Parent CAS No. | 219766-25-3 |
|---|---|
| Chemical Name | N-(2-(2-oxoazepan-3-ylcarbamoyl)phenyl)benzo[b]thiophene-2-carboxamide |
| SMILES | C12=CC=CC=C1C=C(C(NC1=CC=CC=C1C(NC1CCCCNC1=O)=O)=O)S2 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26) |
| InChiKey | TUSCYCAIGRVBMD-UHFFFAOYSA-N |
| CID | 2799722 |
| Short Description | TrkB antagonist |
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