ITD-1, (+)-

Based on 16 publications in PubMed 9 10 16

Axon 2467

CAS [1409968-46-2]

MF C27H29NO3
MW 415.52

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

ITD-1, (+)-

Description

More active (+)-enantiomer of ITD 1 (Axon 2323), a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that acts by clearing the type II TGFβ receptor from the cell surface. ITD 1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-enantiomer is approximately 15-fold more effective than by its (−)-enantiomer.

KEYWORDS: (+)-ITD-1 | supplier | TGF-βR2 inhibitor | ITD1 | (+)-ITD1 | CAS [1409968-46-2] | [1099644-42-4] | [1217467-13-4] | TGF-β | TGF-βR | Antagonist | active enantiomer | Smad | differentiation | cardiomyocytes | cardiogenesis | mESC | stem cell

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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