CU-T12-9

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2455

CAS [1821387-73-8]

MF C17H13F3N4O2
MW 362.31

  • Purity: 100%
  • Soluble in DMSO

CU-T12-9

Description

Selective TLR1/TLR2 agonist (IC50 value 54.4 nM in a competitive binding assay with Pam3CSK4) that facilitates the TLR1/2 heterodimeric complex formation, but not TLR2/6 complex formation. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and inducible NOS.

KEYWORDS: CU-T12-9 | Supplier | TLR1/2 agonist | CUT129 | CAS [1821387-73-8] | DNA-RNA | TLR1 | TLR2 | Modulator | Toll-like receptor | immunology | virus | NF-κB | TNF-α | IL-10 | NOS | vaccine adjuvant | antitumor | interleukin | T-cell

Selective TLR1/TLR2 agonist that facilitates the TLR1/2 complex formation

Chemical name

N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

Parent CAS No.

[1821387-73-8]

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10 mg €120.00 In Stock
50 mg €460.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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