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Motolimod
- VTX-2337 - VTX-378
Axon 2783
CAS:
926927-61-9
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C28H34N4O2
- MW: 458.6
Description
Motolimod is a highly potent and selective TLR8 agonist (EC50 value of 100 nM). Motolimod directly activates myeloid dendritic cells, monocytes, and NK cells, resulting in the production of high levels of mediators including: TNFα, IL-12, and IFNγ, known to orchestrate adaptive antitumor responses.
More Information
| Parent CAS No. | 926927-61-9 |
|---|---|
| Chemical Name | (1E,4E)-2-Amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide |
| SMILES | C1C=C(C2C=CC3C=C(C(N(CCC)CCC)=O)CC(N)=NC=3C=2)C=CC=1C(=O)N1CCCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18H,3-6,13-16,19H2,1-2H3,(H2,29,30) |
| InChiKey | QSPOQCXMGPDIHI-UHFFFAOYSA-N |
| CID | 16049404 |
| Short Description | TLR8 agonist |
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