LHC-165
Axon 3728
CAS:
1258595-14-0
Purity:
99%
- Soluble in DMSO
- MF: C29H32F2N3O7P
- MW: 603.55
Description
LHC-165 is an agonist (activator) of Toll-like Receptor 7 (TLR7), and an immuno-oncology modulator. TLR7 is a protein in the immune system that surveys and recognizes pathological malignance, and triggers the immune response by releasing infection-clearing cytokines if activated. It has demonstrated in mice that LHC-165 induced immune response, and reduced tumor growth, also showed signs of an abscopal effect.
More Information
| Parent CAS No. | 1258595-14-0 |
|---|---|
| Chemical Name | 3-(5-Amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C2N=C(N)C3N=CC(CCC4C(C)=CC(OCCOCCC(F)(F)P(O)(O)=O)=CC=4)=CC=3C=2C=CC=1CCC(=O)O |
| MFCD | N.A. |
| InChi | InChI=1S/C29H32F2N3O7P/c1-18-14-22(41-13-12-40-11-10-29(30,31)42(37,38)39)7-6-21(18)5-2-20-15-24-23-8-3-19(4-9-26(35)36)16-25(23)34-28(32)27(24)33-17-20/h3,6-8,14-17H,2,4-5,9-13H2,1H3,(H2,32,34)(H,35,36)(H2,37,38,39) |
| InChiKey | SDLWKRZBLTZSEL-UHFFFAOYSA-N |
| CID | 49838259 |
| Short Description | Toll-like Receptor 7 agonist |
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