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SMU-L11-R
- Optical Purity: 98% e.e.
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C19H24N4O
- MW: 324.42
Description
SMU-L11-R is a potent and selective Toll-like receptor 7 (TLR7) agonist with an EC50 value of 12 nM against human TLR7. As the biologically active R-(-)-enantiomer of racemic SMU-L11, SMU-L11-R potently activates TLR7-mediated innate immune signaling.
Activation of TLR7 by SMU-L11-R stimulates NF-κB and MAPK signaling pathways, resulting in increased production of pro-inflammatory cytokines including TNF-α and IL-6. In preclinical MC38 colorectal cancer models, combination treatment with SMU-L11-R and PD-L1 checkpoint inhibitors produced a robust antitumor response through activation of both innate and adaptive immunity. Treatment increased infiltration and activation of natural killer (NK) cells, macrophages, dendritic cells, and cytotoxic CD8+ T lymphocytes, leading to enhanced tumor control in vivo.
Key Features
- Potent and selective human TLR7 agonist
- EC50: 12 nM
- Biologically active R-(-)-enantiomer of SMU-L11
- Activates NF-κB and MAPK signaling pathways
- Enhances innate and adaptive antitumor immune responses
Applications
- TLR7 signaling and innate immunity research
- Cancer immunotherapy investigations
- Checkpoint inhibitor combination studies
- NK cell, dendritic cell, and macrophage biology
- Tumor microenvironment and adaptive immune response research
Related Products
SMU-L11 (Axon 4466) is available as the corresponding racemic mixture. SMU-L11-R represents the more active R-(-)-enantiomer and is recommended when maximal TLR7 agonist activity is required.
More Information
| Parent CAS No. | 3040320-18-8 |
|---|---|
| Chemical Name | 4-Butyl-3-(((R)-perhydro-3-furyl)methyl)-3,5,8-triazatricyclo[7.4.0.0²,⁶]trideca-1(13),2(6),4,7,9,11-hexaen-7-ylamine |
| SMILES | C1=C2C3N(C[C@H]4CCOC4)C(CCCC)=NC=3C(N)=NC2=CC=C1 |&1:5,r| |
| InChi | InChI=1/C19H24N4O/c1-2-3-8-16-22-17-18(23(16)11-13-9-10-24-12-13)14-6-4-5-7-15(14)21-19(17)20/h4-7,13H,2-3,8-12H2,1H3,(H2,20,21)/t13-/s3 |
| InChiKey | YRCAPNRYNCJHGV-VHLFKADZNA-N |
| Short Description | TLR7 agonist |
