NRX 194204 - NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2408

CAS [220619-73-8]

MF C24H32O2
MW 352.51

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

NRX 194204

Description

Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively) devoid of any RAR activity (Kd values >30 µM for RARα, RARβ, and RARγ). NRX 194204 blocked the ability of lipopolysaccharide and TNFα to induce the release of nitric oxide and IL6 and the degradation of IKBα in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines.
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Size Unit Price Stock
1 mg €105.00 In Stock
5 mg €265.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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