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BQU 57
Axon 2397
CAS:
1637739-82-2
Purity:
99%
- Soluble in DMSO
- MF: C16H13F3N4O
- MW: 334.3
Description
Inhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 µM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396)
More Information
| Parent CAS No. | 1637739-82-2 |
|---|---|
| Chemical Name | 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
| SMILES | C1C(C(F)(F)F)=CC=C(C2C(C#N)=C(N)OC3N(C)N=C(C)C2=3)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H13F3N4O/c1-8-12-13(9-3-5-10(6-4-9)16(17,18)19)11(7-20)14(21)24-15(12)23(2)22-8/h3-6,13H,21H2,1-2H3 |
| InChiKey | IJCMHHSFXFMZAI-UHFFFAOYSA-N |
| CID | 77845606 |
| Short Description | RalA/B inhibitor |
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