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Axon 2397
CAS [1637739-82-2]
MF C16H13F3N4OMW 334.30
Inhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 µM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396)
6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
[1637739-82-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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