HAMNO - NSC 111847

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2390

CAS [138736-73-9]

MF C17H13NO2
MW 263.29

  • Purity: 99%
  • Soluble in DMSO



Novel protein interaction inhibitor of replication protein A (RPA), a protein involved in the ATR/Chk1 pathway. HAMNO selectively binds the N-terminal DBD-F domain of RPA70, effectively inhibiting critical RPA protein interactions that rely on this domain. HAMNO inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. Candidate therapeutic for cancer treatment, as it enhances the constitutive and oncogene-induced replication stress in cancer cells.
Size Unit Price Stock
10 mg €85.00 In Stock
50 mg €335.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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