WZ 4003

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2385

CAS [1214265-58-3]

MF C25H29ClN6O3
MW 496.99

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

WZ 4003

Description

Specific dual inhibitor of NUAK1 (aka ARK5) and NUAK2 (aka SNARK; IC50 values 20 nM and 100 nM, respectively) with no significant inhibitory effect on a panel of 139 other kinases tested, including ten other AMPK-related kinases. WZ4003 suppressed MYPT1 phosphorylation in a dose-dependent manner, and inhibited cell proliferation, invasion and migration in vivo.
Although WZ 4003 is a close analogue of WZ 4002 (Axon 1506), it shows no affinity for the EGFR (Kd value 14 µM)

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Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €310.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €500.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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