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Axon 2363
CAS [1221277-90-2]
MF C29H28F3NO5S2MW 591.66
The first potent cell-active LXR antagonist (IC50 value 31.6 nM for LXRβ binding). In intact cells stimulated with LXR agonist, GSK 2033 showed a dose-dependent reduction in the expression of the ATP-binding cassette transporter A1 (ABCA1) in THP-1 cells and SREBP-1c in HepG2 cells. A useful chemical probe to explore the cell biology of the LXR receptor.
KEYWORDS: GSK 2033 | supplier | LXR antagonist | GSK2033 | CAS [1221277-90-2] | Metabolism | LXR | Agonist | ATP-binding cassette transporter A1 | ABCA1 | nuclear receptor | NR | lipid | homeostasis | cholesterol
2,4,6-trimethyl-N-((3'-(methylsulfonyl)biphenyl-4-yl)methyl)-N-((5-(trifluoromethyl)furan-2-yl)methyl)benzenesulfonamide
[1221277-90-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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