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GW 3965 hydrochloride
Axon 1266
- Parent CAS: 405911-09-3
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C33H31ClF3NO3.HCl
- MW: 618.51
Description
GW 3965 hydrochloride is a selective and orally active liver X receptor (LXR) full agonist.
LXRα and LXRβ are nuclear receptors that regulate cholesterol efflux, reverse cholesterol transport, lipogenesis and inflammatory gene expression. GW 3965 is widely used to activate LXR-dependent transcription in metabolic and immunological models.
Key Features
- Selective LXR full agonist
- Activates LXRα and LXRβ transcriptional signaling
- Promotes cholesterol efflux pathway research
- Relevant to lipid metabolism and inflammation studies
Applications
- LXR reporter assays
- Cholesterol efflux and ABCA1 pathway studies
- Metabolic disease model research
- Inflammation and macrophage biology assays
More Information
| Parent CAS No. | 405911-09-3 |
|---|---|
| Chemical Name | (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid hydrochloride |
| SMILES | C1C=CC(OCCCN(CC2C(Cl)=C(C(F)(F)F)C=CC=2)CC(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1CC(O)=O.Cl |
| MFCD | MFCD08276920 |
| InChi | InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H |
| InChiKey | NMPUWJFHNOUNQU-UHFFFAOYSA-N |
| CID | 16078973 |
| Short Description | LXR agonist |
GW 3965 hydrochloride
LXR full agonist
GW3965
ABCA1
LXR
Agonist
LXR reporter assays
Cholesterol efflux and ABCA1 pathway studies
Metabolic disease model research
Inflammation and macrophage biology assays
immunology
inflammation
macrophage biology
metabolism
lipid metabolism
receptor selectivity
signal transduction
transcriptional regulation
CAS 405911-09-3
CAS 405911-17-3
Axon Medchem
Axon 1266
Supplier
Vendor
References
- N Mitro et al. The nuclear receptor LXR is a glucose sensor. Nature 2007, 445, 219-223.
- JL Collins et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem. 2002, 45 1963.
- SB Joseph et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl. Acad. Sci. USA 2002, 99 7604.
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