Bulk Inquiry
PX 20350
- FXR agonist Cpd 22
- Soluble in DMSO
- MF: C28H22Cl2F3N3O4
- MW: 592.39
Description
PX 20350 is a potent farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy compared with GW4064 in reported FXR FRET and full-length FXR reporter assays. Reported values include 12 nM in the FRET assay and 6 nM in the direct reporter assay.
FXR is a bile-acid-activated nuclear receptor that regulates bile acid synthesis, lipid metabolism, glucose metabolism and inflammatory responses. PX 20350 is relevant for metabolic disease and hepatobiliary pathway studies.
Key Features
- Potent FXR nuclear receptor agonist
- Enhanced activity compared with GW4064 in reported assays
- Modulates triglyceride and cholesterol pathways in vivo
- Useful bile-acid signaling probe
Applications
- FXR reporter assays
- Bile acid metabolism research
- Lipid and cholesterol pathway studies
- Metabolic and hepatobiliary disease models
More Information
| Parent CAS No. | 1198085-23-2 |
|---|---|
| Chemical Name | 4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)(methyl)amino)methyl)benzoic acid |
| SMILES | C1(C(F)(F)F)N=C(OCC2=C(C3CC3)ON=C2C2C(Cl)=CC=CC=2Cl)C=CC=1N(C)CC1C=CC(C(=O)O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C28H22Cl2F3N3O4/c1-36(13-15-5-7-17(8-6-15)27(37)38)21-11-12-22(34-26(21)28(31,32)33)39-14-18-24(35-40-25(18)16-9-10-16)23-19(29)3-2-4-20(23)30/h2-8,11-12,16H,9-10,13-14H2,1H3,(H,37,38) |
| InChiKey | KNWXWQGSCZVUGX-UHFFFAOYSA-N |
| CID | 44476535 |
| Short Description | FXR agonist |
References
- U. Abel et al. Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. Bioorg. Med. Chem. Lett. 2010, 20, 4911–4917.
- U. Deuschle et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012, 7, e43044.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1266 | GW 3965 hydrochloride |
From $104.50 |
| 1749 | WAY 362450 |
From $137.50 |
| 1991 | WYE 672 |
From $132.00 |
| 2357 | LXR 623 |
From $104.50 |
| 2363 | GSK 2033 |
From $115.50 |
| 2561 | DY 268 |
From $132.00 |
| 2598 | SR 9243 |
From $93.50 |
| 2657 | MGL-3196 |
From $99.00 |
| 3174 | Obeticholic acid |
From $77.00 |
| 4256 | Fexaramine |
From $137.50 |
