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T0901317

Axon 2754
CAS:  293754-55-9
Purity:  98%
  • Soluble in DMSO
  • MF:  C17H12F9NO3S
  • MW:  481.33

Description

T0901317 is a potent liver X receptor (LXR) agonist, with a reported EC50 value of 20 nM. It activates LXR-responsive transcription, including genes involved in cholesterol efflux such as ABCA1 and ABCG1.

T0901317 is widely used to study cholesterol homeostasis, reverse cholesterol transport and lipid-regulated nuclear-receptor signaling. In vivo LXR activation also induces SREBP-1-driven lipogenesis and can elevate triglycerides; the compound additionally modulates other nuclear receptors at higher concentrations, so dose and receptor controls are important.

Key Features

  • Potent LXR agonist (EC50 = 20 nM)
  • Induces cholesterol-efflux pathways
  • Activates SREBP-1-dependent lipogenesis in vivo
  • Concentration-dependent off-target nuclear-receptor activity

Applications

  • LXR nuclear-receptor research
  • Cholesterol-efflux assays
  • ABCA1 and ABCG1 expression studies
  • Lipid-metabolism research
  • Atherosclerosis and metabolic-disease models

More Information

Parent CAS No. 293754-55-9
Chemical Name N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
SMILES C1C=C(S(=O)(=O)N(CC(F)(F)F)C2C=CC(C(C(F)(F)F)(C(F)(F)F)O)=CC=2)C=CC=1
MFCD MFCD03412028
InChi InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChiKey SGIWFELWJPNFDH-UHFFFAOYSA-N
CID 447912
Short Description LXR agonist

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