Bulk Inquiry
Temozolomide
- TMZ - NSC 362856 - SCH 52365 - CCRG 81045
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C6H6N6O2
- MW: 194.15
Description
Chemotherapeutic apoptosis inducer. An orally active alkylating agent prodrug, delivering a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine). Temozolomide has demonstrated efficacy in the treatment of a variety of solid tumors, primary malignant brain tumors and metastatic melanoma (IC50 value 5 μM for cytotoxicity against mouse TLX5 lymphoma cells).
The primary cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltransferase (MGMT; direct repair) in tumours expressing this protein, or tolerated in mismatch repair-deficient (MMR-) tumours.
More Information
| Parent CAS No. | 85622-93-1 |
|---|---|
| Chemical Name | 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
| SMILES | N1(C)C(=O)N2C=NC(C(N)=O)=C2N=N1 |
| MFCD | MFCD00866492 |
| InChi | InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
| InChiKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
| CID | 5394 |
| Short Description | DNA methylating agent |
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