Temozolomide - TMZ | NSC 362856 | SCH 52365 | CCRG 81045

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2326

CAS [85622-93-1]

MW 194.15

  • Purity: 100%
  • Soluble in 0.1N HCl(aq) and DMSO



Chemotherapeutic apoptosis inducer. An orally active alkylating agent prodrug, delivering a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine). Temozolomide has demonstrated efficacy in the treatment of a variety of solid tumors, primary malignant brain tumors and metastatic melanoma (IC50 value 5 μM for cytotoxicity against mouse TLX5 lymphoma cells).
The primary cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltransferase (MGMT; direct repair) in tumours expressing this protein, or tolerated in mismatch repair-deficient (MMR-) tumours.

Size Unit Price Stock
10 mg €50.00 In Stock
50 mg €120.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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