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EUK 134
- Salen-Mn
Axon 2292
CAS:
81065-76-1
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C18H18ClMnN2O4
- MW: 416.74
Description
A salen manganese complex with superoxide dismutase (SOD) and catalase mimetic characteristics. EUK134 exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril (IAPP). Useful pharmacological tool for the development of new compounds for the treatment of Alzheimer's and Parkinson's disease and type 2 diabetes.
More Information
| Parent CAS No. | 81065-76-1 |
|---|---|
| Chemical Name | (SP-5-13) Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-kN)methylidyne]]bis[6-methoxyphenolato-kO]](2-)]-manganese |
| MFCD | MFCD08059577 |
| Short Description | Antioxidant |
References
- S.J. Ophoven et al. Salen-manganese complexes: sophisticated tools for the analysis of intercellular ROS signaling pathways. Anticancer Res. 2010 Oct;30(10):3967-79.
- P. Failli et al. A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury. J Med Chem. 2009 Nov 26;52(22):7273-83.
- D. Decraene et al. A synthetic superoxide dismutase/catalase mimetic (EUK-134) inhibits membrane-damage-induced activation of mitogen-activated protein kinase pathways and reduces p53 accumulation .... J Invest Dermatol. 2004 Feb;122(2):484-91.
- Y. Rong et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9897-902.
- S. Bahramikia et al. Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives. Eur J Pharmacol. 2013 May 5;707(1-3):17-25.
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