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(S)-Trolox
- Optical Purity: 99.8% e.e.
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C14H18O4
- MW: 250.29
Description
(S)-Trolox is a water-soluble analogue of a-tocopherol with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays (trolox equivalent antioxidant capacity). (S)-Trolox is the enantio pure isomer of racemic Trolox which is available as Axon 3514.
More Information
| Parent CAS No. | 53174-06-4 |
|---|---|
| Chemical Name | (S)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| SMILES | C1(O)C(C)=C2CC[C@@](C)(C(O)=O)OC2=C(C)C=1C |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m0/s1 |
| InChiKey | GLEVLJDDWXEYCO-AWEZNQCLSA-N |
| CID | 688071 |
| Short Description | Antioxidant |
References
- I Hamad et al. Intracellular scavenging activity of Trolox (6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid) in the fission yeast, Schizosaccharomyces pombe. J Nat Sci Biol Med. 2010 Jul;1(1):16-21.
- CS Malcolm et al. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radic Biol Med. 2000 Jan 1;28(1):102-7.
- U Uria et al. Gold-catalyzed asymmetric allylic substitution of free alcohols: an enantioselective approach to chiral chromans with quaternary stereocenters for the synthesis of vitamin E and analogues. Chemistry. 2014 Oct 20;20(43):13913-7.
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