Endoxifen, (Z)-

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2221

CAS [112093-28-4]

MF C25H27NO2
MW 373.49

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

Endoxifen, (Z)-

Description

The more active (Z)-isomer of (E/Z)-Endoxifen (Axon 2190), an active metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM; IC50 value 0.01–0.10 μM in estrogen-stimulated proliferation assay in MCF-7 cells); Potently inhibits the growth of estrogen-stimulated BT474 cells.
Approximately 100-fold more potent as an antagonist of the ERα than the parent drug. Z-Endoxifen may provide a new and better treatment for women with estrogen receptor (ER) positive breast cancer.

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5 mg €155.00 In Stock
25 mg €620.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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