(Z)-Endoxifen

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2221

CAS [112093-28-4]

MF C25H27NO2
MW 373.49

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

(Z)-Endoxifen

Description

The more active (Z)-isomer of (E/Z)-Endoxifen (Axon 2190), an active metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM; IC50 value 0.01–0.10 μM in estrogen-stimulated proliferation assay in MCF-7 cells); Potently inhibits the growth of estrogen-stimulated BT474 cells.
Approximately 100-fold more potent as an antagonist of the ERα than the parent drug. Z-Endoxifen may provide a new and better treatment for women with estrogen receptor (ER) positive breast cancer.

P. Elkins et al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D-NMR, high resolution LC-MS, and quantitative HPLC analysis. J. Pharm. Biomed. Anal. 2014, 88, 174-179.

J.R. Hawse et al. Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens. PLoS One. 2013, 8, e54613.

A Ahmad et al. Endoxifen, a New Cornerstone of Breast Cancer Therapy: Demonstration of Safety, Tolerability, and Systemic Bioavailability in Healthy Human Subjects. Clin. Pharmacol. Ther. 2010, 88(6), 814–817.

M.D. Johnson et al. Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen. Breast Cancer Research and Treatment 2004, 85, 151-159.

The more active (Z)-isomer of Endoxifen (SERM; Axon 2190)

Chemical name

(Z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol

Parent CAS No.

[112093-28-4]

Order

Size	Unit Price	Stock
5 mg	€150.00	In Stock
25 mg	€600.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1231	PPT	ER-α agonist	€95.00
1232	DPN	Estrogen (ER-β) agonist	€70.00
1748	Bazedoxifene hydrochloride	Selective estrogen receptor modulator (SERM)	€70.00
1898	ERB 041	Selective estrogen receptor β (ERβ) agonist	€95.00
1926	Estetrol	Estrogen receptor agonist (four- to five-fold preference for the Erα)	€130.00
2190	Endoxifen	Selective estrogen receptor modulator (SERM)	€125.00
2051	Bazedoxifene acetate	Selective estrogen receptor modulator (SERM)	€80.00
2337	XCT 790	ERRα inverse agonist and potent mitochondrial uncoupler	€120.00
2652	ZB716	Steroidal, orally bioavailable SERD	€130.00
2707	Endoxifen hydrochloride	Selective estrogen receptor modulator (SERM)	€130.00
2697	WAY-200070	Brain penetrant ERβ-selective agonist	€105.00
2790	BHPI	ER-α antagonist	€125.00
3252	Tamoxifen	Selective estrogen receptor modulator (SERM)	€50.00
3250	Raloxifene	Selective estrogen receptor modulator (SERM)	€50.00
3320	Diethylstilbestrol	Estrogen receptor agonist	€50.00
3322	Dehydroepiandrosterone	Endogenous steroid hormone precursor	€60.00
3650	Clomiphene citrate	Selective estrogen receptor modulator (SERM)	€50.00
4095	Elacestrant dihydrochloride	Orally bioavailable selective estrogen receptor degrader (SERD)	€220.00
4093	(Z)-4-Hydroxytamoxifen	The more active metabolite of Tamoxifen (SERM; Axon 3252)	€110.00
4212	α-Estradiol	Endogenous estrogen receptor ligand	€90.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

(Z)-Endoxifen

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

(Z)-Endoxifen

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us