Metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM); Potently inhibits the growth of estrogen-stimulated BT474 cells (IC50: 54 nM). Approximately 100-fold more potent as an antagonist of the ERα than the parent drug. Drug for the treatment of estrogen receptor (ER) positive breast cancer.
The water soluble hydrochloride salt Endoxifen hydrochloride is available as Axon 2707. The more active isomer, Z-Endoxifen, is available as Axon 2221.

KEYWORDS: Endoxifen | supplier | SERM | 4OHNDtam | N-Desmethyl-4-hydroxytamoxifen | CAS [110025-28-0] | Estrogen | Selective Estrogen Receptor | Modulator | Nuclear receptor | metabolite | ER positive breast cancer | Tamoxifen