5-HT6 receptor antagonist (Ki value 0.83 nM for h5-HT6) demonstrating >50-fold selectivity for more than 70 targets examined, with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Idalopirdine (Lu AE58054) potentiates the effects of Donepezil (Axon 1438) on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus.

KEYWORDS: Lu AE58054 hydrochloride | supplier | 5-HT6 antagonist | Idalopirdine HCl | LuAE58054 | CAS [467458-02-2] | [467459-31-0] | Serotonin | 5-HT6 | Antagonist | cognitive | schizophrenia | Donepezil | neuronal | oscillations | hippocampus