Lu AE58054 hydrochloride - Idalopirdine HCl

Based on 201 reference(s) in Google Scholar 9 10 201

Axon 2144

CAS [467458-02-2]

MF C20H19F5N2O.HCl
MW 434.83

  • Purity: 100%
  • Soluble in water and DMSO

Lu AE58054 hydrochloride

Description

5-HT6 receptor antagonist (Ki value 0.83 nM for h5-HT6) demonstrating >50-fold selectivity for more than 70 targets examined, with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Idalopirdine (Lu AE58054) potentiates the effects of Donepezil (Axon 1438) on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus.

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KEYWORDS: Lu AE58054 hydrochloride | supplier | 5-HT6 antagonist | Idalopirdine HCl | LuAE58054 | CAS [467458-02-2] | [467459-31-0] | Serotonin | 5-HT6 | Antagonist | cognitive | schizophrenia | Donepezil | neuronal | oscillations | hippocampus

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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