PF 431396

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2107

CAS [717906-29-1]

MF C22H21F3N6O3S
MW 506.50

Purity: 99%
Soluble in DMSO

PF 431396

Description

Dual focal adhesion kinase (FAK or PTK2) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with high affinity IC50 values of 1.5 nM and 11 nM for FAK and PYK2 respectively; PF 431396 increases bone formation and protects against bone loss in ovariectomized rats

L Buckbinder et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc. Nat. Acad. Sci. 2007, 104(25), 10619-10624.

S Han et al. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J. Biol. Chem. 2009, 19, 13193-13201.

DP Walker et al. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg. Med. Chem. Let. 2009, 19(12), 3253-3258.

Dual FAK(PTK2) and PYK2 inhibitor

Chemical name

N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide

Parent CAS No.

[717906-29-1]

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Size	Unit Price	Stock
5 mg	€80.00	In Stock
25 mg	€280.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€130.00	In Stock

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PF 431396

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PF 431396

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