Voriconazole - Vfend | UK 109496

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2044

CAS [137234-62-9]

MF C16H14F3N5O
MW 349.31

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Voriconazole

Description

Orally bioavailable CYP51 inhibitor; Antifungal agent; Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase (CYP51, P450-DM), resulting in a depletion of ergosterol in fungal cell membrane.

L.J. Scott et al. Voriconazole : a review of its use in the management of invasive fungal infections. Drugs. 2007, 67, 269-298.

M. Sandherr et al. Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. Eur. J. Med. Res. 2011, 16, 139-144.

Cell Signaling & Oncology Diabetes & Metabolism Immunology EC 1.14.13.70 Cytochrome P450 Infectious Disease

Orally bioavailable CYP51 inhibitor; Antifungal agent

Chemical name

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Parent CAS No.

[137234-62-9]

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Voriconazole - Vfend | UK 109496

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