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Voriconazole
- Vfend - UK 109496
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C16H14F3N5O
- MW: 349.31
Description
Voriconazole is an orally bioavailable azole CYP51/lanosterol 14α-demethylase inhibitor. It inhibits fungal ergosterol biosynthesis, disrupting membrane sterol composition and antifungal viability.
Fungal CYP51 is an essential enzyme in ergosterol production and a validated antifungal drug target. Voriconazole is useful for studying azole antifungal pharmacology, sterol biosynthesis and fungal susceptibility mechanisms.
Key Features
- Azole antifungal CYP51 inhibitor
- Blocks fungal ergosterol biosynthesis
- Orally bioavailable pharmacological profile
- Relevant to fungal sterol pathway research
Applications
- CYP51 enzyme assays
- Antifungal susceptibility testing
- Fungal membrane biology studies
- Azole resistance mechanism research
More Information
| Parent CAS No. | 137234-62-9 |
|---|---|
| Chemical Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
| extra_info | . |
| SMILES | [C@](O)(CN1C=NC=N1)([C@@H](C)C1=NC=NC=C1F)C1=CC=C(C=C1F)F |&1:0,8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
| InChiKey | BCEHBSKCWLPMDN-MGPLVRAMSA-N |
| CID | 71616 |
| Short Description | CYP51 inhibitor |
References
- L.J. Scott et al. Voriconazole : a review of its use in the management of invasive fungal infections. Drugs. 2007, 67, 269-298.
- M. Sandherr et al. Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. Eur. J. Med. Res. 2011, 16, 139-144.
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