PF 5274857 hydrochloride - PF 05274857 hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2027

CAS [1373615-35-0]

MF C20H25ClN4O3S.HCl
MW 473.42

  • Purity: 99%
  • Soluble in water and DMSO

PF 5274857 hydrochloride

Description

Potent and selective smoothened (SMO) antagonist with Ki value of 4.6 nM; a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway
Smoothened (SMO) antagonist

Chemical name

1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[1373615-35-0]

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5 mg €110.00 In Stock
25 mg €390.00 In Stock
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2 x 25 mg €620.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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