JQ-1, (+)- - JQ1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1989

CAS [1268524-70-4]

MF C23H25ClN4O2S
MW 456.99

  • Purity: 99%
  • Optical purity: 99% ee
  • Soluble in DMSO

JQ-1, (+)-

Description

Potent and selective BET bromodomain inhibitor (IC50 values of 77 nM and 33 nM for inhibition of binding of a tetra-acetylated histone H4 peptide to BRD4 with the first and second bromodomain, respectively). (+)-JQ1 is capable of blocking the macrophage inflammatory responses via inhibition of BET proteins in mice, and activating HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Cotreatment with JQ1 and the FLT3 inhibitor AC220 (Axon 1696) synergistically induce apoptosis of cultured and primary CD34(+) human AML blast progenitor cells (BPC) expressing FLT3-ITD.

KEYWORDS: (+)-JQ-1 | BET inhibitor | JQ1 | JQ-1 | JQ1 | CAS [1268524-70-4] | Histone | BET (BRD) | Inhibitor | Proteins | Bromodomain | inflammatory | HIV latency

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Size Unit Price Stock
2 mg €70.00 In Stock
5 mg €105.00 In Stock
25 mg €365.00 In Stock
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2 x 5 mg €160.00 In Stock
2 x 25 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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