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GW 5074
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H8Br2INO2
- MW: 520.94
Description
GW 5074 is a potent, cell-permeable c-Raf/Raf-1 inhibitor with reported IC50 activity of 9 nM in biochemical assays. It has been used to interrogate Raf-MEK-ERK signaling and neuronal survival pathways.
Raf kinases are upstream activators of MEK and ERK signaling, linking growth factor inputs to proliferation and survival. GW 5074 is pharmacologically relevant for kinase signaling studies and for models examining ERK-dependent neuroprotection.
Key Features
- Potent c-Raf/Raf-1 inhibitor
- Reported IC50: 9 nM in vitro
- Modulates Raf-MEK-ERK signaling biology
- Used in neuronal survival and neurodegeneration models
Applications
- Raf kinase inhibition assays
- MEK/ERK pathway studies
- Neuroprotection model research
- Kinase pathway selectivity profiling
More Information
| Parent CAS No. | 220904-83-6 |
|---|---|
| Chemical Name | 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one |
| SMILES | N1C2=C(C=C(I)C=C2)/C(=C/C2=CC(Br)=C(O)C(Br)=C2)/C1=O |
| MFCD | MFCD03453076 |
| InChi | InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- |
| InChiKey | LMXYVLFTZRPNRV-KMKOMSMNSA-N |
| CID | 5924208 |
| Short Description | C-Raf inhibitor |
References
- PC Chin et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem. 2004 Aug;90(3):595-608.
- K. Lackey et al. The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.
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