GW 5074

Based on 241 publications in PubMed 9 10 241

Axon 1984

CAS [220904-83-6]

MW 520.94

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

GW 5074


Potent, brain-permeable inhibitor of c-Raf (IC50 value 9 nM) when tested in vitro with no effect on the activities of CDK1/2/5/6, JNK1/2/3, c-Src, MEK1, p38 MAP kinase, VEGFR2, and c-fms. In contrast to its effect in vitro, treatment of neurons with GW 5074 causes c-Raf activation (when measured in vitro inthe absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW 5074 protects neurons from death in culture and in an in vivo paradigm of neurodegeneration.

KEYWORDS: GW 5074 | supplier | C-Raf inhibitor | GW5074 | CAS [220904-83-6] | MEK | RAF | Inhibitor | Raf-1 | cell-permeable | activation | Raf-MEK-ERK | pathway | CNS | neurodegeneration | neuroprotection

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5 mg €85.00 In Stock
25 mg €285.00 In Stock
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Size Unit Price Stock
2 x 5 mg €130.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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