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MRT 10
Axon 1938
CAS:
330829-30-6
Purity:
99%
- Soluble in DMSO
- MF: C24H23N3O5S
- MW: 465.52
Description
Smoothened (SMO) receptor antagonist
More Information
| Parent CAS No. | 330829-30-6 |
|---|---|
| Chemical Name | N-(3-benzamidophenylcarbamothioyl)-3,4,5-trimethoxybenzamide |
| SMILES | C(NC(NC1=CC=CC(NC(=O)C2=CC=CC=C2)=C1)=S)(=O)C1=CC(OC)=C(OC)C(OC)=C1 |
| MFCD | MFCD02734587 |
| InChi | InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33) |
| InChiKey | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
| CID | 1139102 |
| Short Description | SMO antagonist |
References
- F Manetti et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010, 78(4), 658-665.
- A Solinas et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J. Med. Chem. 2012, 55(4), 1559-1571.
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