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MG 132
- Z-Leu-leu-leu-al
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C26H41N3O5
- MW: 475.62
Description
More Information
| Parent CAS No. | 133407-82-6 |
|---|---|
| Chemical Name | benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate |
| SMILES | O(CC1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(N[C@H](C(=O)N[C@@H](CC(C)C)C([H])=O)CC(C)C)=O |&1:11,18,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1 |
| InChiKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| CID | 462382 |
| Short Description | Proteasome inhibitor |
References
- D Banerjee and A Liefshitz. Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 2001, 21(6A), 3941-3947.
- VJ Palombella et al. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994, 78(5), 773-785.
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