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VU 0238429
- Soluble in DMSO and EtOH
- MF: C17H12F3NO4
- MW: 351.28
Description
VU 0238429 is a highly selective M5 muscarinic acetylcholine receptor positive allosteric modulator (PAM).
M5 receptors are implicated in CNS cholinergic modulation and dopaminergic circuitry. VU 0238429 is useful for studying M5-selective allosteric potentiation and dissecting muscarinic receptor subtype pharmacology.
Key Features
- Selective M5 muscarinic receptor PAM
- Enhances CHRM5 receptor signaling allosterically
- Useful for subtype-selective muscarinic pharmacology
- Supports CNS cholinergic circuit studies
Applications
- M5 receptor pharmacology
- Allosteric GPCR modulator assays
- Cholinergic and dopaminergic circuit research
- Muscarinic receptor subtype selectivity profiling
More Information
| Parent CAS No. | 1160247-92-6 |
|---|---|
| Chemical Name | 1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione |
| SMILES | C1(OC(F)(F)F)C=C2C(=O)C(=O)N(CC3C=CC(OC)=CC=3)C2=CC=1 |
| MFCD | MFCD16618396 |
| InChi | InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 |
| InChiKey | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
| CID | 42633508 |
| Short Description | M5 PAM |
References
- TM Bridges et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J. Med. Chem. 2009, 52(11), 3445–3448.
- PJ Conn et al. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol. Sci. 2009, 30(3), 148–155.
- TM Bridges et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg. Med. Chem. Lett. 2010, 20(19), 5617.
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