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CHIR124
- CHIR-124
Axon 1636
CAS:
405168-58-3
- Optical Purity: >98% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H22ClN5O
- MW: 419.91
Description
Potent, cell permeable and selective Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
More Information
| Parent CAS No. | 405168-58-3 |
|---|---|
| Chemical Name | (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one |
| SMILES | N([C@@H]1CN2CCC1CC2)C1C2=CC(Cl)=CC=C2NC(=O)C=1C1=NC2=CC=CC=C2N1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1 |
| InChiKey | MOVBBVMDHIRCTG-LJQANCHMSA-N |
| CID | 135399748 |
| Short Description | CHK1 inhibitor |
References
- ZJ Ni et al. 4-(Aminoalkylamino)-3-benzimidazolequinolinones as potent CHK-1 inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(12), 3121-3124.
- AN Tse et al. CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo. Clin. Cancer Res. 2007, 13, 591-602.
- Y Tao et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle. 2009, 8(8), 1196-205.
- JL Smith. Role of checkpoint kinase 1 in malignant melanoma. PhD thesis 2013, University of Glasgow, UK.
- List of publications using CHIR124 (Axon 1636) purchased from Axon Medchem
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