NVP-LDE225 - LDE 225 | Sonidegib | Erismodegib

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Axon 1619

CAS [956697-53-3]

MF C26H26F3N3O3
MW 485.50

Purity: 98%
Soluble in DMSO

NVP-LDE225

Description

Potent, selective and orally bioavailable Smoothened (SMO) antagonist (IC50: 50 nM); it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO)

S Pan et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.

Certificate of Analysis
Material Safety Data Sheet

Smoothened (SMO) antagonist

Chemical name

N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide

Parent CAS No.

[956697-53-3]

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NVP-LDE225 - LDE 225 | Sonidegib | Erismodegib

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NVP-LDE225 - LDE 225 | Sonidegib | Erismodegib

Description

Chemical name

Parent CAS No.

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