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Ziprasidone hydrochloride
- CP 88059
- Parent CAS: 146939-27-7
- Soluble in DMSO
- MF: C21H21ClN4OS.HCl
- MW: 449.4
Description
A 5-HT2A/5-HT2C and dopamine D2 antagonist, 5-HT1A agonist; an atypical antipsychotic for the treatment of schizophrenia and acute bipolar disorder including manic and mixed episodes; Oral bioavailability 59%; Antipsychotic effects at oral doses of 20 mg.
More Information
| Parent CAS No. | 146939-27-7 |
|---|---|
| Chemical Name | 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-Indol-2-one hydrochloride |
| extra_info | . |
| SMILES | C1C2NC(=O)CC=2C=C(CCN2CCN(C3=NSC4C=CC=CC3=4)CC2)C=1Cl.Cl |
| MFCD | MFCD06795476 |
| InChi | InChI=1S/C21H21ClN4OS.ClH/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;/h1-4,11,13H,5-10,12H2,(H,23,27);1H |
| InChiKey | NZDBKBRIBJLNNT-UHFFFAOYSA-N |
| CID | 219099 |
| Short Description | Atypical antipsychotic |
References
- DC Goff et al. An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder. J. Clin. Psychopharmacol 1998, 18(4), 296-304.
- CB Nemeroff et al. From clinical research to clinical practice: a 4-year review of ziprasidone. CNS Spectr 2005, 10 (11 Suppl 17), 1–20.
- TF Seeger et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J. Pharmacol. Exp. Ther. 2005, 275(1), 101–13.
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