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Donepezil hydrochloride
Axon 1438
- Parent CAS: 120014-06-4
Purity:
99%
- Soluble in water and DMSO
- MF: C24H29NO3.HCl
- MW: 415.95
Description
A centrally acting reversible acetylcholinesterase (AChE) inhibitor, with 100% oral bioavailability and easily crossing the blood-brain barrier; therapeutic agent in the treatment of Alzheimer's disease
More Information
| Parent CAS No. | 120014-06-4 |
|---|---|
| Chemical Name | 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one hydrochloride |
| SMILES | C1(OC)C=C2CC(CC3CCN(CC4C=CC=CC=4)CC3)C(=O)C2=CC=1OC.Cl |
| MFCD | MFCD00881312 |
| InChi | InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H |
| InChiKey | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
| CID | 5741 |
| Short Description | AChE inhibitor |
References
- J Birks, RJ Harvey. Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev 2006, (1): CD001190.
- LS Steele, RH Glazier. Is donepezil effective for treating Alzheimer's disease? Can Fam Physician 1999, 45, 917–9.
- G Xiong, PM Doraiswamy. Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?. Geriatrics 2005, 60(6), 22–6.
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