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Amoxapine
- Soluble in DMSO
- MF: C17H16ClN3O
- MW: 313.78
Description
Amoxapine is a tricyclic antidepressant pharmacology reference compound that acts as a strong norepinephrine reuptake inhibitor and weaker serotonin reuptake inhibitor.
Amoxapine is also notable because its major metabolite 7-hydroxyamoxapine displays dopamine receptor blocking activity. This mixed monoamine transporter and metabolite-mediated receptor profile is useful in antidepressant and antipsychotic pharmacology research.
Key Features
- Strong norepinephrine reuptake inhibitor profile
- Weaker serotonin reuptake inhibition
- Major metabolite has dopamine receptor blocking activity
- Useful reference for tricyclic antidepressant pharmacology
Applications
- Monoamine transporter uptake assays
- Antidepressant mechanism studies
- Dopamine receptor-related metabolite research
- Norepinephrine and serotonin signaling models
More Information
| Parent CAS No. | 14028-44-5 |
|---|---|
| Chemical Name | 2-Chloro-11-piperazin-1-yl-dibenzo[b,f][1,4]oxazepine |
| SMILES | O1C2C=CC(Cl)=CC=2C(N2CCNCC2)=NC2C=CC=CC1=2 |
| MFCD | MFCD00069210 |
| InChi | InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 |
| InChiKey | QWGDMFLQWFTERH-UHFFFAOYSA-N |
| CID | 2170 |
| Short Description | Tricyclic antidepressant |
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