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Venlafaxine hydrochloride
- Venlift - Vexor - WY 45030
- Parent CAS: 93413-69-5
- Soluble in water and DMSO
- MF: C17H27NO2.HCl
- MW: 313.86
Description
Venlafaxine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) that inhibits monoamine transporter-mediated reuptake of serotonin and norepinephrine.
Venlafaxine is a clinically established antidepressant and a useful reference compound for monoamine transporter pharmacology, SNRI metabolism and active metabolite profiling.
Key Features
- SNRI targeting serotonin and norepinephrine reuptake
- Reference compound for monoamine transporter pharmacology
- Clinically established antidepressant mechanism
- Parent compound for multiple venlafaxine metabolite standards
Applications
- SERT and NET transporter assays
- Antidepressant mechanism research
- Drug metabolism and pharmacokinetic studies
- Analytical comparison with venlafaxine metabolites
Related venlafaxine metabolites available from stock:
| R-(-)-O-Desmethylvenlafaxine (Axon 1720) |
| S-(+)-O-Desmethylvenlafaxine (Axon 1721) |
| Deshydroxy Venlafaxine HCl (Axon 1722) |
| WY 45960 hydrochloride (Axon 1723) |
| WY 45494 hydrochloride (Axon 1724) |
| WY 46689 (Axon 1725) |
| Dinorvenlafaxine (Axon 1726) |
| O-Desmethylvenlafaxine succinate (Axon 2116) |
| O-Desmethylvenlafaxine hydrochloride (Axon 3555) |
| O-Desmethylvenlafaxine (Axon 3578) |
More Information
| Parent CAS No. | 93413-69-5 |
|---|---|
| Chemical Name | 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride |
| SMILES | C1(C(CN(C)C)C2(CCCCC2)O)C=CC(OC)=CC=1.Cl |
| MFCD | MFCD00864385 |
| InChi | InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H |
| InChiKey | QYRYFNHXARDNFZ-UHFFFAOYSA-N |
| CID | 62923 |
| Short Description | SNRI |
References
- EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
- FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
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