Bulk Inquiry
BMS 189961
- BMS 961
- Soluble in DMSO
- MF: C23H26FNO4
- MW: 399.46
Description
BMS 189961 is a potent and selective nuclear retinoic acid receptor gamma (RARγ) agonist with an EC₅₀ of 30 nM in transactivation assays, highly selective for RARγ compared to RARβ (where it has an EC₅₀ of 1,000 nM). Its more active (R)-(+)-enantiomer, BMS 270394 (Axon 1173), is available separately for enantiomer-specific retinoid receptor studies.
RARγ signaling controls transcriptional programs involved in differentiation, development and epithelial biology. BMS 189961 supports research into retinoid receptor activation and stereochemistry-dependent nuclear receptor pharmacology.
Key Features
- Potent and selective RARγ agonist
- Comparator to the more active BMS 270394 enantiomer
- Nuclear receptor ligand
- Useful for retinoid signaling studies
Applications
- RARγ receptor pharmacology
- Retinoic acid signaling research
- Cell differentiation studies
- Enantiomeric nuclear receptor profiling
More Information
| Parent CAS No. | 185629-22-5 |
|---|---|
| Chemical Name | 3-Fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid |
| SMILES | C1=C(C(O)C(=O)NC2C=CC(C(=O)O)=CC=2F)C=CC2C(C)(C)CCC(C)(C)C1=2 |
| MFCD | MFCD18711373 |
| InChi | InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29) |
| InChiKey | AANFHDFOMFRLLR-UHFFFAOYSA-N |
| CID | 2418 |
| Short Description | RAR-γ agonist |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1173 | BMS 270394 |
From $181.50 |
| 1241 | CH 55 |
From $99.00 |
| 1242 | LE 135 |
From $132.00 |
| 1700 | Bexarotene |
From $71.50 |
| 2408 | NRX 194204 |
From $132.00 |
| 2637 | LY 2955303 dihydrochloride |
From $159.50 |
| 2679 | AR7 |
From $99.00 |
| 2902 | QX77 |
From $132.00 |
| 2948 | AM 580 |
From $110.00 |
| 3321 | Retinoic acid |
From $55.00 |
