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SR 48692
- Meclinertant
Axon 1164
CAS:
146362-70-1
Purity:
99%
- Soluble in DMSO
- MF: C32H31ClN4O5
- MW: 587.07
Description
SR 48692 (Meclinertant) is an orally active, non-peptide, high-affinity neurotensin NTS1 receptor antagonist. It is used to block neurotensin receptor signaling in CNS, gastrointestinal and cancer-related pathway studies.
NTS1 receptors mediate neurotensin effects on dopamine pathways, pain processing, gut motility and cell proliferation. SR 48692 is a well-established antagonist tool for neurotensin receptor pharmacology.
Key Features
- High-affinity NTS1 receptor antagonist
- Non-peptide and orally active
- Blocks neurotensin receptor signaling
- Useful for CNS and gastrointestinal pathway research
Applications
- NTS1 receptor pharmacology
- Neurotensin signaling studies
- Dopamine-neurotensin pathway research
- Cancer and gastrointestinal receptor models
More Information
| Parent CAS No. | 146362-70-1 |
|---|---|
| Chemical Name | 2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid |
| SMILES | N(C1(C(=O)O)C2CC3CC(C2)CC1C3)C(=O)C1=NN(C2C3=CC=C(Cl)C=C3N=CC=2)C(C2C(OC)=CC=CC=2OC)=C1 |
| MFCD | MFCD03106260 |
| InChi | InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40) |
| InChiKey | DYLJVOXRWLXDIG-UHFFFAOYSA-N |
| CID | 119192 |
| Short Description | NT1 antagonist |
References
- Horger et al. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization.Neuropsychopharmacology 1994, 11, 215-222.
- Croci et al. Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats. Br. J. Pharmacol. 1997, 120, 1312–1318.
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