Bulk Inquiry
GMC 1-169
- Soluble in DMSO
- MF: C19H19F3N4O3S
- MW: 440.44
Description
GMC 1-169 is an atypical antipsychotic-like research compound described as lacking muscarinic activity. It is useful for studying antipsychotic profiles that separate atypical CNS effects from muscarinic receptor engagement.
Muscarinic receptor activity contributes to both pharmacological and side-effect profiles of many antipsychotics. GMC 1-169 provides a comparator for examining antipsychotic-like receptor patterns without strong muscarinic contribution.
Key Features
- Atypical antipsychotic-like research compound
- Described as lacking muscarinic activity
- Useful comparator for receptor-profile studies
- Supports CNS antipsychotic mechanism research
Applications
- Atypical antipsychotic profiling
- Muscarinic-sparing CNS pharmacology
- Dopamine-serotonin receptor comparison
- Antipsychotic SAR studies
More Information
| Parent CAS No. | 183140-97-8 |
|---|---|
| Chemical Name | 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-yl trifluoromethanesulfonate |
| SMILES | N1C2C=CC=CC=2NC2C=CC(OS(C(F)(F)F)(=O)=O)=CC=2C=1N1CCN(C)CC1 |
| MFCD | MFCD00951800 |
| InChi | InChI=1S/C19H19F3N4O3S/c1-25-8-10-26(11-9-25)18-14-12-13(29-30(27,28)19(20,21)22)6-7-15(14)23-16-4-2-3-5-17(16)24-18/h2-7,12,23H,8-11H2,1H3 |
| InChiKey | XKXPMSXRABANAG-UHFFFAOYSA-N |
| CID | 9954899 |
| Short Description | Atypical antipsychotic |
References
- Liao, Y. et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of Clozapine: Identification of a novel atypical neuroleptic. J. Med. Chem. 1997, 40, 4146-4153.
- Y. Liao et al. New sulfonyloxy piperazinyldibenzazapines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J. Med. Chem. 1999,42, 2235-2244.
- Jackson, D; Wikström, H; Liao, Y. Is clozapine an (partial) agonist at both dopamine D1 and D2 receptors? Psychopharm. 1998, 138, 213-214.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1086 | WAY 100635 hydrochloride |
From $137.50 |
| 1087 | Desmethyl-WAY 100635 trihydrochloride |
From $159.50 |
| 1141 | Sertindole |
From $90.20 |
| 1143 | Aripiprazole |
From $82.50 |
| 1144 | Thio-aripiprazole |
From $154.00 |
| 1146 | Clozapine |
From $55.00 |
| 1147 | Isoclozapine |
From $148.50 |
| 1149 | GMC 61-39 |
From Inquiry |
| 1150 | GMC 2-83 |
From $176.00 |
| 1151 | GMC 1-116 |
From $154.00 |
| 1152 | GMC 1-165 |
From $154.00 |
| 1236 | SKF 83566 hydrobromide |
From $99.00 |
| 1298 | Olanzapine |
From $82.50 |
| 1354 | Quetiapine fumarate |
From $82.50 |
| 1381 | Amisulpride |
From $49.50 |
| 1446 | Ziprasidone hydrochloride |
From $55.00 |
| 1454 | Risperidone |
From $82.50 |
| 1493 | Iloperidone |
From $93.50 |
| 1503 | Asenapine maleate |
From $77.00 |
| 1508 | Bifeprunox mesylate |
From $88.00 |
| 2127 | Fluphenazine decanoate dihydrochloride |
From $66.00 |
| 2335 | Brexpiprazole dihydrochloride |
From $148.50 |
| 2353 | Blonanserin |
From $71.50 |
| 2424 | WAY 100635 maleate |
From $137.50 |
