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CP 154526 hydrochloride
Axon 1116
- Parent CAS: 157286-86-7
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C23H32N4.HCl
- MW: 400.99
Description
Corticotropin-releasing factor CRF1 antagonist
More Information
| Parent CAS No. | 157286-86-7 |
|---|---|
| Chemical Name | Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-ethyl-amine hydrochloride |
| SMILES | C1(C)C(N2C3N=C(C)N=C(N(CC)CCCC)C=3C(C)=C2)=C(C)C=C(C)C=1.Cl |
| MFCD | MFCD00930935 |
| InChi | InChI=1S/C23H32N4.ClH/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5;/h12-14H,8-11H2,1-7H3;1H |
| InChiKey | ZWDLBNCJWNENFF-UHFFFAOYSA-N |
| CID | 11475094 |
| Short Description | CRF1 antagonist |
References
- SPH Alexander et al. Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol. 2007, 150 (Suppl. 1), S1–S168.
- Lundkist et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur. J. Pharmacol. 1996, 309, 195.
- Schulz et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA 1996, 93 10477.
- Hodgson et al. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol. Biochem. Behav. 2007, 86, 431.
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