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SB 271046 hydrochloride
Axon 1099
- Parent CAS: 209481-20-9
Purity:
99%
- Soluble in DMSO
- MF: C20H22ClN3O3S2.HCl
- MW: 488.45
Description
Putative 5-HT6 antagonist
More Information
| Parent CAS No. | 209481-20-9 |
|---|---|
| Chemical Name | 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-methoxy-3-piperazin-1-yl-phenyl)-amide hydrochloride |
| SMILES | C1(Cl)=CC2C(C)=C(S(=O)(NC3C=C(N4CCNCC4)C(OC)=CC=3)=O)SC=2C=C1.Cl |
| MFCD | MFCD10565914 |
| InChi | InChI=1S/C20H22ClN3O3S2.ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24;/h3-6,11-12,22-23H,7-10H2,1-2H3;1H |
| InChiKey | RMXZRJYGJMSDQK-UHFFFAOYSA-N |
| CID | 6918455 |
| Short Description | 5-HT6 antagonist |
References
- SM Bromidge et al. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J. Med. Chem. 1999, 42(2), 202-5.
- C Routledge et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br. J. Pharmacol. 2000, 130(7), 1606-1612.
- AG Foley et al. The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacol. 2004, 29(1), 93-100.
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