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8-Hydroxy-DPAT hydrobromide
- 8-OH-DPAT
- Parent CAS: 78950-78-4
- Soluble in DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
8-Hydroxy-DPAT hydrobromide is a standard selective 5-HT1A receptor agonist. The racemate is widely used as a serotonergic tool compound, with the R-(+)-enantiomer (Axon 1016) being more active than the S-(-)-enantiomer (Axon 1017).
5-HT1A receptors regulate serotonergic neurotransmission, mood-related pathways, thermoregulation and neuronal excitability. 8-Hydroxy-DPAT hydrobromide is commonly used to activate 5-HT1A receptors in in vitro and in vivo pharmacology models.
Key Features
- Selective 5-HT1A receptor agonist
- Standard serotonergic reference agonist
- Racemic 8-OH-DPAT hydrobromide
- Enantiomer-specific activity can be assessed using the R-(+) and S-(-) forms
Applications
- 5-HT1A receptor signaling studies
- Serotonergic neurotransmission research
- GPCR agonist assay development
- Behavioral and neuropharmacology models
More Information
| Parent CAS No. | 78950-78-4 |
|---|---|
| Chemical Name | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide |
| SMILES | C1C(O)=C2CC(N(CCC)CCC)CCC2=CC=1.Br |
| MFCD | MFCD00055158 |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H |
| InChiKey | BATPBOZTBNNDLN-UHFFFAOYSA-N |
| CID | 6917794 |
| Short Description | 5-HT1A agonist |
References
- T Yoshitake and J Kehr. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004, 74, 2865.
- LJ Cornfield et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 1991, 39, 780.
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