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Sephin 1
- NSC 65390
- Soluble in DMSO
- MF: C8H9ClN4
- MW: 196.64
Description
Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin1 selectively disrupted the PPP1R15A-PP1c complex, therebye prolonging eIF2α phosphorylation after stress, delaying translation recovery, and consequently, attenuated expression of stress genes such as the pro-apoptotic protein CHOP. The cytoprotectant prevents protein misfolding, motor deficits, motor neuron loss, and the molecular defects in SOD1 mutant mice.
More Information
| Parent CAS No. | 951441-04-6 |
|---|---|
| Chemical Name | (E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide |
| SMILES | N(C(N)=N)/N=C/C1=CC=CC=C1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+ |
| InChiKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |
| CID | 9561611 |
| Short Description | PPP1R15A inhibitor |
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