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CU-T12-9
- Soluble in DMSO
- MF: C17H13F3N4O2
- MW: 362.31
Description
Selective TLR1/TLR2 agonist (IC50 value 54.4 nM in a competitive binding assay with Pam3CSK4) that facilitates the TLR1/2 heterodimeric complex formation, but not TLR2/6 complex formation. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and inducible NOS.
More Information
| Parent CAS No. | 1821387-73-8 |
|---|---|
| Chemical Name | N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline |
| SMILES | C1([N+]([O-])=O)C=C(N2C=NC(C3C=CC(C(F)(F)F)=CC=3)=C2)C(NC)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13F3N4O2/c1-21-14-7-6-13(24(25)26)8-16(14)23-9-15(22-10-23)11-2-4-12(5-3-11)17(18,19)20/h2-10,21H,1H3 |
| InChiKey | LITXVDAFEYLWQE-UHFFFAOYSA-N |
| CID | 91826088 |
| Short Description | TLR1/TLR2 agonist |
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