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15-LOX-1 inhibitor i472
Axon 2989
CAS:
2349374-37-2
Purity:
98%
- Soluble in DMSO
- MF: C22H21ClN2O4
- MW: 412.87
Description
Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor i472 shows an ability to protect RAW 264.7 macrophages from LPS-induced cell death. Furthermore, i472 is shown to provide significant inhibition of NF-κB transcriptional activation upon LPS/INFγ stimulation, to downregulate the expression of the NF-κB related gene iNOS, to provide dose-dependent inhibition of NO production and to reduce lipid peroxidation in RAW macrophages.
*Sold in collaboration with RuG (University of Groningen)
More Information
| Parent CAS No. | 2349374-37-2 |
|---|---|
| Chemical Name | (E)-Ethyl 6-chloro-3-(3-(2-methoxybenzylamino)-3-oxoprop-1-enyl)-1H-indole-2-carboxylate |
| extra_info | Sold in collaboration with RuG (University of Groningen) |
| SMILES | C1C=C2C(/C=C/C(NCC3C(OC)=CC=CC=3)=O)=C(C(=O)OCC)NC2=CC=1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21ClN2O4/c1-3-29-22(27)21-17(16-9-8-15(23)12-18(16)25-21)10-11-20(26)24-13-14-6-4-5-7-19(14)28-2/h4-12,25H,3,13H2,1-2H3,(H,24,26)/b11-10+ |
| InChiKey | BRMZRDPEXXAZRV-ZHACJKMWSA-N |
| CID | 145874872 |
| Short Description | Lipoxygenase inhibitor |
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